Article
Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
Biochimica et biophysica acta. Biomembranes - 1 Nov 2020
Kurokawa Yuna, Konishi Rikako, Yoshida Akane, Tomioku Kanna, Tanabe Kenji, Fujita Akikazu
Abstract excerpt
Morphologically, the lipophagy in yeast cell mimics microautophagy, which includes a direct amendment of the vacuolar membrane that engulfs lipid droplets (LDs). The molecular mechanism of the membrane modifications that elicits microautophagy still remains elusive. In this study, an analysis of membrane lipid distribution at a nanoscale level showed that PtdIns(4)P is localized in the cytoplasmic leaflet of...
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