Article
A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis.
Autophagy - 1 Jan 2015
Maeda Yuichiro, Oku Masahide, Sakai Yasuyoshi
Abstract excerpt
Lipid droplets (LDs) are the conserved organelles for the deposit of neutral lipids, and function as reservoirs of membrane and energy sources. To date, functional links between autophagy and LD dynamics have not been fully elucidated. Here, we report that a vacuolar putative lipase, Atg15, required for degradation of autophagic bodies, is crucial for the maintenance of LD amount in the yeast Saccharomyces...
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