Article

Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis

2023-07-24

Abstract excerpt

Phosphatidylinositol (PI)-4-phosphate (PI4P) is a lipid found at the plasma membrane (PM) and Golgi in cells from yeast to humans. PI4P is generated from PI by PI4-kinases and can be converted to PI-4,5-bisphosphate [PI(4,5)P 2 ]. Schizosaccharomyces pombe have 2 essential PI4-kinases: Stt4 and Pik1. Stt4 localizes to the PM and its loss from the PM results in a decrease of PM PI4P and PI(4,5)P 2 . As a result,...

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Literature Corpus work: 0bf638f1-c6e0-571c-aa85-b0803f0b9417
DOI: 10.1101/2023.07.24.550375

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