Article
Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast.
Journal of cell science - 4 Jan 2018
Yamamoto Wataru, Wada Suguru, Nagano Makoto, Aoshima Kaito, Siekhaus Daria Elisabeth, Toshima Junko Y, Toshima Jiro
Abstract excerpt
Clathrin-mediated endocytosis requires the coordinated assembly of various endocytic proteins and lipids at the plasma membrane. Accumulating evidence demonstrates a crucial role for phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in endocytosis but specific roles for phosphatidylinositol-4-phosphate [PtdIns(4)P], other than as the biosynthetic precursor of PtdIns(4,5)P2, have not been clarified. In this...
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