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Article

Hypoxia inducible factor-1α regulates autophagy via the p27-E2F1 signaling pathway

1 Feb 2017

Abstract excerpt

Autophagy is a highly conserved process by which the cell contents are delivered to lysosomes for degradation, or are used to provide macromolecules for energy generation under conditions of nutritional starvation. It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)‑1α, in order to adapt...

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PMID: 28627618
DOI: 10.3892/mmr.2017.6794

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