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Article

HIF1A regulates xenophagic degradation of adherent and invasive<i>Escherichia coli</i>(AIEC)

14 Nov 2014

Abstract excerpt

The hypoxia inducible transcription factor HIF1 activates autophagy, a general catabolic pathway involved in the maintenance of cellular homeostasis. Dysfunction in both autophagy and HIF1 has been implicated in an increasing number of human diseases, including inflammatory bowel disease (IBD), such as Crohn disease (CD). Adherent invasive E. coli (AIEC) colonize ileal mucosa of CD patients and strongly promote...

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PMID: 25484075
DOI: 10.4161/15548627.2014.984275

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