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Article

Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination

1 Sept 2022

Abstract excerpt

The intestinal mucosa exists in a state of "physiologic hypoxia," where oxygen tensions are markedly lower than those in other tissues. Intestinal epithelial cells (IECs) have evolved to maintain homeostasis in this austere environment through oxygen-sensitive transcription factors, including hypoxia-inducible factors (HIFs). Using an unbiased chromatin immunoprecipitation (ChIP) screen for HIF-1 targets, we...

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PMID: 36170839
DOI: 10.1016/j.celrep.2022.111409

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