Article
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.
Nature genetics - 1 Sept 2020
Maciejowski John, Chatzipli Aikaterini, Dananberg Alexandra, Chu Kevan, Toufektchan Eleonore, Klimczak Leszek J, Gordenin Dmitry A, Campbell Peter J, de Lange Titia
Abstract excerpt
Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes1-5. Here we examine the mechanism underlying chromothripsis and kataegis by using an in vitro telomere crisis model. We show that the cytoplasmic exonuclease TREX1, which promotes the...
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