Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics.

Journal of clinical pharmacology - 1 Mar 2006

Williams J Andrew, Johnson Keith, Paulauskis Joseph, Cook Jack

Abstract excerpt

Based on current literature, greater clarity in defining the magnitude of polymorphism effects on pharmacokinetics can be achieved by addressing key components of study design, including adequate subject numbers per study group. Convincing evidence of functional relevance exists for polymorphisms in genes such as CYP2D6 and UGT1A1, whereas the published evidence for similar effects for CYP3A5, OATP1B1, and ABCB1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Clinical Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzymes

Share to Glucuronosyltransferase

Share to Metabolic Clearance Rate

Share to Patient Selection

Share to Pharmacokinetics

Share to Research Design

Source

Identifiers

PMID: 16490801
DOI: 10.1177/0091270005283463

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics.PMID 16490801Read ↗

P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.Semantic proximity Read ↗

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.Semantic proximity Read ↗

Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokineticsSemantic proximity Read ↗

Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.Semantic proximity Read ↗

Substrate specificity of CYP2D6 genetic variants.Semantic proximity Read ↗

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.Semantic proximity Read ↗

Using population pharmacokinetic analyses of drugs metabolized by CYP2D6 to study the genotype-phenotype translation.Semantic proximity Read ↗

Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of DrugsSemantic proximity Read ↗

Should Race-Genotype Interactions Be Considered in the Global Development of CYP2C19 Substrates? A Proposed Framework Using Physiologically Based Pharmacokinetic Modeling.Semantic proximity Read ↗

Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.Semantic proximity Read ↗

Effect of Genotype on the Pharmacokinetics and Bleeding Events of Direct Oral Anticoagulants: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.