Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.

The pharmacogenomics journal - 1 Jun 2007

Leschziner G D, Andrew T, Pirmohamed M, Johnson M R

Abstract excerpt

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of diseases. It is postulated that ABCB1 polymorphisms contribute to variability in PGP function, and that therefore multidrug resistance is, at least in part, genetically determined. However, studies of ABCB1 genotype or haplotype and PGP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to CD4 Lymphocyte Count

Share to Digoxin

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Immunosuppressive Agents

Share to Organic Anion Transporters

Source

Identifiers

PMID: 16969364
DOI: 10.1038/sj.tpj.6500413

Genes

PGP
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.PMID 16969364Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

Pharmacogenomic importance of ABCG2.Semantic proximity Read ↗

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.Semantic proximity Read ↗

The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans.Semantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.Semantic proximity Read ↗

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Semantic proximity Read ↗

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2Semantic proximity Read ↗

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.