Article
Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2020
Anderson Kirsten M, Augusto Danillo G, Dandekar Ravi, Shams Hengameh, Zhao Chao, Yusufali Tasneem, Montero-Martín Gonzalo, Marin Wesley M, Nemat-Gorgani Neda, Creary Lisa E, Caillier Stacy, Mofrad Mohammad R K, Parham Peter, Fernández-Viña Marcelo, Oksenberg Jorge R, Norman Paul J, Hollenbach Jill A
Abstract excerpt
Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells regulate immune functions and are modulated by killer cell immunoglobulin-like receptors (KIR). KIR are expressed on the surface of NK cells and interact with HLA class I ligands on the surface of all nucleated cells. We investigated KIR-allelic polymorphism to interrogate the role of NK cells in PD. We sequenced KIR genes from...
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