Article

Natural killer cells are a potential source of oxidative stress in inclusion body myositis

2025-05-07

Abstract excerpt

Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy in individuals over 50 years of age. IBM is considered a T cell-mediated disease. In contrast, the role of natural killer (NK) cells remains understudied. Here, we characterized the phenotype and function of peripheral NK cells in 22 IBM patients and 22 age-matched non-diseased controls. Flow cytometry revealed stable overall NK cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23ac4d5f-e2fc-5814-8602-f8282655fc4e
DOI: 10.1101/2025.05.05.25326736

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Natural killer cells are a potential source of oxidative stress in inclusion body myositisDOI 10.1101/2025.05.05.25326736Read

Inclusion Body MyositisSemantic proximity Read

Immunohistochemical Phenotype of T Cells Invading Muscle in Inclusion Body Myositis.Semantic proximity Read

Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity.Semantic proximity Read

NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body MyositisSemantic proximity Read

Immune and myodegenerative pathomechanisms in inclusion body myositisSemantic proximity Read

Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies.Semantic proximity Read

Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositisSemantic proximity Read

Human induced pluripotent stem cell-derived myotubes to model inclusion body myositisSemantic proximity Read

Risk factors and disease mechanisms in myositis.Semantic proximity Read

Sporadic inclusion body myositis-derived myotube culture revealed muscle cell-autonomous expression profilesSemantic proximity Read

Th1 response and systemic treg deficiency in inclusion body myositis.Semantic proximity Read

An update on pathogenic mechanisms of inflammatory myopathiesSemantic proximity Read