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Article

Nuclear delivery mechanism of herpes simplex virus type 1 genome

1 Apr 2011

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential, poorly understood multistep process, referred to as uncoating. Uncoating steps are as follows: (1) The incoming capsid pinpoints the nuclear pore complex (NPC). (2) It opens up at the NPC and releases the highly pressurized viral genome. (3) The viral...

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PMID: 21504018
DOI: 10.1002/jmr.1120

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