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Article

A possible contribution of endothelial <scp>CCN</scp>1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis

24 Nov 2014

Abstract excerpt

CCN1 is a pleiotropic molecule involved in angiogenesis and postnatal vasculogenesis, both of which are impaired in systemic sclerosis (SSc). To elucidate the potential role of CCN1 in the development of SSc, we investigated CCN1 expression in the lesional skin of SSc patients and SSc animal models and the clinical correlation of serum CCN1 levels. CCN1 expression was markedly decreased in dermal small blood...

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PMID: 25421497
DOI: 10.1111/exd.12602

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