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Article

Selection of mutant µplasmin for amyloid-β cleavage in vivo.

Scientific reports - 21 Jul 2020

Yang Dongying, Zhu Wei, Wang Yingjie, Tan Fangmei, Ma Zhiping, Gao Jiali, Lin Xinli

Abstract excerpt

One of the main culprits of Alzheimer's disease (AD) is the formation of toxic amyloid-β (Aβ) peptide polymers and the aggregation of Aβ to form plaques in the brain. We have developed techniques to purify the catalytic domain of plasmin, micro-plasmin (µPlm), which can be used for an Aβ-clearance based AD therapy. However, in serum, µPlm is irreversibly inhibited by its principal inhibitor α2-antiplasmin...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32694536
DOI: 10.1038/s41598-020-69079-8
PMCID: PMC7374754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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