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Article

Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction.

Blood - 16 Jun 2011

Uitte de Willige Shirley, Miedzak Megan, Carter Angela M, Lisman Ton, Rosendaal Frits R, Grant Peter J, Philippou Helen, Ariëns Robert A S

Abstract excerpt

Alpha-2-antiplasmin (α2AP) undergoes both N- and C-terminal cleavages, which significantly modify its activities. Compared with other Ser protease inhibitors (serpins), α2AP contains an ~50-residue-extended C-terminus, which binds plasmin(ogen). We developed 2 new ELISAs to measure the antigen levels of free total α2AP and free C-terminally intact α2AP to investigate whether α2AP antigen levels or α2AP C-terminal...

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Identifiers

PMID: 21505192
DOI: 10.1182/blood-2010-11-320325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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