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Article

Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin.

Biochemistry - 18 Jun 1996

Markland W, Ley A C, Lee S W, Ladner R C

Abstract excerpt

We generated a series of libraries having variants of the first Kunitz domain of human lipoprotein-associated coagulation inhibitor (LACI-D1, also known as tissue-factor pathway inhibitor-I) displayed on bacteriophage M13 as pIII-fusions. We varied LACI-DI iteratively in two regions: the P1 region (positions 10-21) and the "second loop", (positions 31-39), which together form one end of the domain. Display-phage...

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Identifiers

PMID: 8672509
DOI: 10.1021/bi9526286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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