Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin.

doi:10.1021/bi9526286

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Article

Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin.

Biochemistry - 18 Jun 1996

Markland W, Ley A C, Lee S W, Ladner R C

Abstract excerpt

We generated a series of libraries having variants of the first Kunitz domain of human lipoprotein-associated coagulation inhibitor (LACI-D1, also known as tissue-factor pathway inhibitor-I) displayed on bacteriophage M13 as pIII-fusions. We varied LACI-DI iteratively in two regions: the P1 regio...

Topics

Amino Acid Sequence
Aprotinin
Bacteriophage M13
Base Sequence
Fibrinolysin
Gene Library
Genetic Variation
Humans
Lipoproteins
Models, Structural
Molecular Sequence Data
Mutagenesis, Insertional
Protein Structure, Secondary
Restriction Mapping
Sequence Homology, Amino Acid
Serine Proteinase Inhibitors
Thrombin

Source

Open in PubMed

Identifiers

PMID: 8672509
DOI: 10.1021/bi9526286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8672509-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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