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Article

Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.

The international journal of biochemistry & cell biology - 1 Aug 2014

Lim Kyungeun, Kim Meehyein, Lee Mi-Kyung, Ko Junsang, Hong Sungwoo, Choi Byong-Seok

Abstract excerpt

Influenza RNA polymerase is composed of three subunits, PA, PB1, and PB2, which interact with each other for transcription and replication of the viral RNA genome in the nucleus of infected cells. PB2 RNA-binding 627-domain (residues 535-693), located in the C-terminus, presents a highly basic surface around residue lysine 627 and has been proposed to interact with viral or cellular factors, resulting in host...

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Identifiers

PMID: 24875650
DOI: 10.1016/j.biocel.2014.05.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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