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Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

1 Sept 2017

Abstract excerpt

Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an uncharacterized 33 amino-acid insertion that is present in avian ANP32A. Here, we uncover important contributions of host SUMOylation to vPol activity, including...

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PMID: 28903035
DOI: 10.1016/j.celrep.2017.08.061

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