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Article

Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder.

BMC bioinformatics - 10 Jan 2022

Yang James J, Luo Xi, Trucco Elisa M, Buu Anne

Abstract excerpt

BACKGROUND/AIM: The polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as alcohol use disorder that is influenced by a combination of multiple variants, each of which has a very small effect. Yet, conventional PRS methods tend to over-adjust confounding factors in the discovery sample and thus have low power to predict the phenotype in...

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PMID: 35012447
DOI: 10.1186/s12859-022-04566-5
PMCID: PMC8744290

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