Article
Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma.
Allergy - 1 Dec 2016
Nieuwenhuis M A, Siedlinski M, van den Berge M, Granell R, Li X, Niens M, van der Vlies P, Altmüller J, Nürnberg P, Kerkhof M, van Schayck O C, Riemersma R A, van der Molen T, de Monchy J G, Bossé Y, Sandford A, Bruijnzeel-Koomen C A, Gerth van Wijk R, Ten Hacken N H, Timens W, Boezen H M, Henderson J, Kabesch M, Vonk J M, Postma D S, Koppelman G H
Abstract excerpt
BACKGROUND: Genomewide association studies (GWASs) of asthma have identified single-nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to identify susceptibility genes for asthma combined with BHR and analyse the presence of cis-eQTLs among replicated...
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