Article
Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2016
Nakamura Y, Suzuki R, Mizuno T, Abe K, Chiba S, Horii Y, Tsuboi J, Ito S, Obara W, Tanita T, Kanno H, Yamauchi K
Abstract excerpt
BACKGROUND: Several gene variants identified in bronchial asthmatic patients are associated with a decrease in pulmonary function. The effects of this intervention on pulmonary function have not been fully researched. OBJECTIVE: We determined the effects of high-dose inhaled corticosteroids (ICSs) on decreased pulmonary function in asthmatic Japanese patients with variants of IL13 and STAT4 during long-term...
Topics
- Administration, Inhalation
- Adrenal Cortex Hormones
- Airway Remodeling
- Alleles
- Anti-Asthmatic Agents
- Asthma
- Biomarkers
- Bronchoalveolar Lavage Fluid
- Cytokines
- Eosinophils