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Article

SLCO1B1 Functional Variants, Bilirubin, Statin-Induced Myotoxicity, and Recent Sub-Saharan African Ancestry: A Precision Medicine Health Equity Study.

Clinical pharmacology and therapeutics - 1 Jun 2025

Haldar Tanushree, Kvale Mark, Yang Jia, Douglas Michael P, Coyote-Maetas Willow, Kachuri Linda, Witte John S, Iribarren Carlos, Medina Marisa W, Krauss Ronald M, Yee Sook Wah, Oni-Orisan Akinyemi

Abstract excerpt

Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines. The objective of this precision medicine health equity study was to determine the clinical validity of understudied candidate functional...

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Identifiers

PMID: 40047317
DOI: 10.1002/cpt.3624
PMCID: PMC12087686

Genes

SLCO1B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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SLCO1B1 Functional Variants, Bilirubin, Statin-Induced Myotoxicity, and Recent Sub-Saharan African Ancestry: A Precision Medicine Health Equity Study.PMID 40047317Read ↗

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