Article
Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America - 17 Oct 2017
Walls Alexandra C, Tortorici M Alejandra, Snijder Joost, Xiong Xiaoli, Bosch Berend-Jan, Rey Felix A, Veesler David
Abstract excerpt
The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. The coronavirus spike (S) glycoprotein initiates infection by promoting fusion of the viral and cellular membranes through conformational changes that remain largely uncharacterized. Here we report the cryoEM structure of a coronavirus S glycoprotein in the postfusion...
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