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Structural snapshots of phenuivirus cap-snatching and transcription

19 Apr 2024

Abstract excerpt

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a human pathogen that is now endemic to several East Asian countries. The viral large (L) protein catalyzes viral transcription by stealing host mRNA caps via a process known as cap-snatching. Here, we establish an in vitro cap-snatching assay and present three high-quality electron cryo-microscopy (cryo-EM) structures of the SFTSV L protein in...

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PMID: 38709882
DOI: 10.1093/nar/gkae330

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