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Article

A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

8 Jun 2015

Abstract excerpt

RNA-dependent RNA polymerases (RdRPs) from the Flaviviridae family are representatives of viral polymerases that carry out RNA synthesis through a de novo initiation mechanism. They share a ≈ 600-residue polymerase core that displays a canonical viral RdRP architecture resembling an encircled right hand with palm, fingers, and thumb domains surrounding the active site. Polymerase catalytic motifs A-E in the palm...

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PMID: 26062131
DOI: 10.3390/ijms160612943

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