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Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication

23 May 2023

Abstract excerpt

Hantaviruses are causing life-threatening zoonotic infections in humans. Their tripartite negative-stranded RNA genome is replicated by the multi-functional viral RNA-dependent RNA-polymerase. Here we describe the structure of the Hantaan virus polymerase core and establish conditions for in vitro replication activity. The apo structure adopts an inactive conformation that involves substantial folding...

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PMID: 37221161
DOI: 10.1038/s41467-023-38555-w

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