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Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

21 May 2015

Abstract excerpt

Segmented negative-strand RNA virus (sNSV) polymerases transcribe and replicate the viral RNA (vRNA) within a ribonucleoprotein particle (RNP). We present cryo-EM and X-ray structures of, respectively, apo- and vRNA bound La Crosse orthobunyavirus (LACV) polymerase that give atomic-resolution insight into how such RNPs perform RNA synthesis. The complementary 3' and 5' vRNA extremities are sequence specifically...

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Identifiers

PMID: 26004069
DOI: 10.1016/j.cell.2015.05.006

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