Article
Host methylglyoxal activates the Listeria virulence program, allowing bacteria to evade inflammatory phagocytes by cell-to-cell spread.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2026
Anaya-Sanchez Andrea, Ragunathan Preethi T, Hung Angela, Van Alst Andrew J, Lobanovska Mariya, Stanley Sarah A, Portnoy Daniel A
Abstract excerpt
Methylglyoxal is a reactive aldehyde produced by macrophages as part of their antimicrobial innate immune arsenal. Our prior work showed that Listeria monocytogenes relies on glyoxalase A (GloA) and bacterial glutathione to detoxify methylglyoxal and that loss of GloA severely impairs bacterial virulence in mice and results in a 100 to 1,000 increase in bacterial mutation frequency. Glutathione is required for...
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