Article
Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease.
Diseases of the colon and rectum - 1 Feb 2012
Sehgal Rishabh, Berg Arthur, Polinski Joseph I, Hegarty John P, Lin Zhenwu, McKenna Kevin J, Stewart David B, Poritz Lisa S, Koltun Walter A
Abstract excerpt
BACKGROUND: There are no clear criteria for judging the severity of disease in patients with Crohn's disease. Yet classification of patients into low- and high-risk severity groups would benefit both medical and surgical management. At the time of this study, approximately 80 single-nucleotide polymorphisms within 55 genes had been associated with IBD. OBJECTIVE: The aim of this study was to identify genetic...
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