A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease.

doi:10.1093/ibd/izy094

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease.

Inflammatory bowel diseases - 8 Jun 2018

Gisbert-Ferrándiz Laura, Salvador Pedro, Ortiz-Masiá Dolores, Macías-Ceja Dulce Carolina, Orden Samuel, Esplugues Juan Vicente, Calatayud Sara, Hinojosa Joaquín, Barrachina Maria Dolores, Hernández Carlos

Abstract excerpt

Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a higher risk of Crohn's disease (CD). We analyzed differences in VDR expression levels among CD patients who were homozygous for allelic variants in this SNP and their relevance for disease course. Methods: DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Crohn Disease

Share to Homozygote

Share to Interleukin-1beta

Share to Polymorphism, Restriction Fragment Length

Share to Receptors, Calcitriol

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 29788141
DOI: 10.1093/ibd/izy094

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease.PMID 29788141Read ↗

ApaI Polymorphism in the Vitamin D Receptor Gene Decreases the Risk of Perianal Fistulas in Crohn's Disease.Semantic proximity Read ↗

Association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with Crohn's disease in Chinese patients.Semantic proximity Read ↗

The role of Vitamin D level and related single nucleotide polymorphisms in Crohn's disease.Semantic proximity Read ↗

Genetic Polymorphisms (ApaI, FokI, BsmI, and TaqI) of the Vitamin D Receptor (VDR) Influence the Natural History and Phenotype of Crohn’s DiseaseSemantic proximity Read ↗

Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.Semantic proximity Read ↗

The vitamin D receptor Taq I polymorphism is associated with reduced VDR and increased PDIA3 protein levels in human intestinal fibroblasts.Semantic proximity Read ↗

Vitamin D Receptor Gene Single Nucleotide Polymorphisms and Association With Vitamin D Levels and Endoscopic Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Study.Semantic proximity Read ↗

[An analysis of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels in patients with Crohn's disease].Semantic proximity Read ↗

Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.Semantic proximity Read ↗

The Role of Vitamin D and Vitamin D Receptors in Colon CancerSemantic proximity Read ↗

Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population.Semantic proximity Read ↗

Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.