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Article

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

12 Apr 2019

Abstract excerpt

Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, inactivating mutations in just one allele are responsible for a distinct yet rare clinical syndrome, DYRK1A haploinsufficiency. Moreover, altered expression of this kinase may also provoke other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30979931
DOI: 10.1038/s41598-019-42445-x

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