Article
Proteogenomics connects somatic mutations to signalling in breast cancer.
Nature - 2 Jun 2016
Mertins Philipp, Mani D R, Ruggles Kelly V, Gillette Michael A, Clauser Karl R, Wang Pei, Wang Xianlong, Qiao Jana W, Cao Song, Petralia Francesca, Kawaler Emily, Mundt Filip, Krug Karsten, Tu Zhidong, Lei Jonathan T, Gatza Michael L, Wilkerson Matthew, Perou Charles M, Yellapantula Venkata, Huang Kuan-lin, Lin Chenwei, McLellan Michael D, Yan Ping, Davies Sherri R, Townsend R Reid, Skates Steven J, Wang Jing, Zhang Bing, Kinsinger Christopher R, Mesri Mehdi, Rodriguez Henry, Ding Li, Paulovich Amanda G, Fenyö David, Ellis Matthew J, Carr Steven A
Abstract excerpt
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of 105 genomically annotated breast cancers, of which 77 provided high-quality data. Integrated analyses provided insights into the somatic cancer...
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