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Article

Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2020

Chen Yongping, Gu Xiaojing, Ou Ruwei, Zhang Lingyu, Hou Yanbing, Liu Kuncheng, Cao Bei, Wei Qianqian, Li Chunyu, Song Wei, Zhao Bi, Wu Ying, Cheng Jingqiu, Shang Huifang

Abstract excerpt

BACKGROUND: Defects in the α-synuclein, leucine-rich repeat kinase 2, or glucocerebrosidase genes have been regarded as essential contributors to PD. However, genetic variability of these genes with respect to early-onset PD remains poorly defined for the Chinese demographic. OBJECTIVES: We aim to systematically characterize the clinical and genetic architecture of α-synuclein, leucine-rich repeat kinase 2, and...

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PMID: 32677286
DOI: 10.1002/mds.28191

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