Article
Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations.
Human molecular genetics - 15 Jul 2014
Foo Jia Nee, Tan Louis C, Liany Herty, Koh Tat Hung, Irwan Ishak D, Ng Yen Yek, Ahmad-Annuar Azlina, Au Wing-Lok, Aung Tin, Chan Anne Y Y, Chong Siow-Ann, Chung Sun Ju, Jung Yusun, Khor Chiea Chuen, Kim Juyeon, Lee Jimmy, Lim Shen-Yang, Mok Vincent, Prakash Kumar-M, Song Kyuyoung, Tai E-Shyong, Vithana Eranga N, Wong Tien-Yin, Tan Eng-King, Liu Jianjun
Abstract excerpt
To evaluate the contribution of non-synonymous-coding variants of known familial and genome-wide association studies (GWAS)-linked genes for Parkinson's disease (PD) to PD risk in the East Asian population, we sequenced all the coding exons of 39 PD-related disease genes and evaluated the accumulation of rare non-synonymous-coding variants in 375 early-onset PD cases and 399 controls. We also genotyped 782...
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