Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence and genotype-phenotype correlations of GBA-related Parkinson disease in a large Chinese cohort.

European journal of neurology - 1 Apr 2022

Ren Jingru, Zhang Ronggui, Pan Chenxi, Xu Jianxia, Sun Haochen, Hua Ping, Zhang Li, Zhang Wenbin, Xu Pingyi, Ma Changyan, Liu Weiguo

Abstract excerpt

BACKGROUND AND PURPOSE: Variants in the glucocerebrosidase (GBA) gene are recognized as a common and important genetic risk factor for Parkinson disease (PD). However, the impact of variant severity on the clinical phenotype of PD in the Chinese population remains unclear. Thus, the present study aimed to determine the frequency of GBA-related PD (GBA-PD) and the relationship of GBA variant severity with clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to China
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Glucosylceramidase

Share to Lysosomal Storage Disorders Research

Share to Mutation

Share to Parkinson Disease

Share to Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 34951095
DOI: 10.1111/ene.15230
PMCID: PMC9303336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and genotype-phenotype correlations of GBA-related Parkinson disease in a large Chinese cohort.PMID 34951095Read ↗

GBA-Related Parkinson's Disease: Dissection of Genotype-Phenotype Correlates in a Large Italian Cohort.Semantic proximity Read ↗

Association of GBA genotype with motor and cognitive decline in Chinese Parkinson’s disease patientsSemantic proximity Read ↗

Exploring the Genotype–Phenotype Correlation in GBA-Parkinson Disease: Clinical Aspects, Biomarkers, and Potential ModifiersSemantic proximity Read ↗

Severe<i>GBA1</i>variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trialsSemantic proximity Read ↗

Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals.Semantic proximity Read ↗

Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease.Semantic proximity Read ↗

A Global Perspective of GBA1-Related Parkinson's Disease: A Narrative Review.Semantic proximity Read ↗

Glucocerebrosidase (GBA) gene variants in a multi-ethnic Asian cohort with Parkinson's disease: mutational spectrum and clinical features.Semantic proximity Read ↗

GBA Variants Influence Motor and Non-Motor Features of Parkinson's Disease.Semantic proximity Read ↗

Penetrance of Parkinson’s disease in<i>GBA1</i>carriers is depending on the variant severity and polygenic backgroundSemantic proximity Read ↗

Beyond Parkinson’s disease: expanding the neurodegenerative spectrum of GBA1- associated disordersSemantic proximity Read ↗

Classification of GBA1 Variants in Parkinson's Disease: The GBA1-PD Browser.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.