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Article

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal

16 Jul 2020

Abstract excerpt

Life-long production of blood from hematopoietic stem cells (HSCs) is a process of strict modulation. Intrinsic and extrinsic signals govern fate options like self-renewal - a cardinal feature of HSCs. Bone morphogenetic proteins (BMP) have an established role in embryonic hematopoiesis, but less is known about its functions in adulthood. Previously, SMAD-mediated BMP signaling has been proven dispensable for...

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PMID: 32675226
DOI: 10.3324/haematol.2019.236125

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