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Article

BMP4 regulates the hematopoietic stem cell niche

16 Sept 2009

Abstract excerpt

Bone morphogenetic protein 4 (BMP4) is required for mesoderm commitment to the hematopoietic lineage during early embryogenesis. However, deletion of BMP4 is early embryonically lethal and its functional role in definitive hematopoiesis is unknown. Consequently, we used a BMP4 hypomorph to investigate the role of BMP4 in regulating hematopoietic stem cell (HSC) function and maintaining steady-state hematopoiesis...

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Identifiers

PMID: 19759357
DOI: 10.1182/blood-2009-02-206433

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