Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smad4 is critical for self-renewal of hematopoietic stem cells

12 Mar 2007

Abstract excerpt

Members of the transforming growth factor beta (TGF-beta) superfamily of growth factors have been shown to regulate the in vitro proliferation and maintenance of hematopoietic stem cells (HSCs). Working at a common level of convergence for all TGF-beta superfamily signals, Smad4 is key in orchestrating these effects. The role of Smad4 in HSC function has remained elusive because of the early embryonic lethality...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Pluripotent Stem Cells Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17353364
DOI: 10.1084/jem.20060465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smad4 is critical for self-renewal of hematopoietic stem cellsPMID 17353364Read ↗

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewalSemantic proximity Read ↗

Smad7 promotes self-renewal of hematopoietic stem cellsSemantic proximity Read ↗

Complex and Context Dependent Regulation of Hematopoiesis by TGF‐β Superfamily SignalingSemantic proximity Read ↗

A Road Map Toward Defining the Role of Smad Signaling in Hematopoietic Stem CellsSemantic proximity Read ↗

The role of Smad signaling in hematopoiesisSemantic proximity Read ↗

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.Semantic proximity Read ↗

BMP4 regulates the hematopoietic stem cell nicheSemantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

Smad4 haploinsufficiency: a matter of dosageSemantic proximity Read ↗

SMAD4 TGF-β–independent function preconditions naive CD8+ T cells to prevent severe chronic intestinal inflammationSemantic proximity Read ↗

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal TractSemantic proximity Read ↗

Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.