Article
Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
PloS one - 1 Jan 2020
Murovets Vladimir O, Lukina Ekaterina A, Sozontov Egor A, Andreeva Julia V, Khropycheva Raisa P, Zolotarev Vasiliy A
Abstract excerpt
In mammals, inter- and intraspecies differences in consumption of sweeteners largely depend on allelic variation of the Tas1r3 gene (locus Sac) encoding the T1R3 protein, a sweet taste receptor subunit. To assess the influence of Tas1r3 polymorphisms on feeding behavior and metabolism, we examined the phenotype of F1 male hybrids obtained from crosses between the following inbred mouse strains: females from...
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