Article
Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jan 2004
Reed D R, Li S, Li X, Huang L, Tordoff M G, Starling-Roney R, Taniguchi K, West D B, Ohmen J D, Beauchamp G K, Bachmanov A A
Abstract excerpt
The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to the Tas1r3 (taste receptor) gene. The goal of this study was to identify Tas1r3 sequence variants associated with saccharin preference in a large number of inbred mouse strains. Initially, we sequenced approximately 6.7 kb of the Tas1r3 gene and its flanking regions from six inbred mouse strains with high and low...
Topics
- Animals
- Choice Behavior
- Food Preferences
- Gene Expression
- Gene Frequency
- Genotype
- Male
- Mice
- Mice, Inbred Strains
- Polymorphism, Genetic
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Saccharin