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Article

Exploiting CRISPR Cas9 in Three-Dimensional Stem Cell Cultures to Model Disease

24 Jun 2020

Abstract excerpt

Three-dimensional (3D) cell culture methods have been widely used on a range of cell types, including stem cells to modulate precisely the cellular biophysical and biochemical microenvironment and control various cell signaling cues. As a result, more in vivo-like microenvironments are recapitulated, particularly through the formation of multicellular spheroids and organoids, which may yield more valid mechanisms...

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PMID: 32671050
DOI: 10.3389/fbioe.2020.00692

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