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Article

Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2017

Watkins Jaclyn C, Howitt Brooke E, Horowitz Neil S, Ritterhouse Lauren L, Dong Fei, MacConaill Laura E, Garcia Elizabeth, Lindeman Neal I, Lee Larissa J, Berkowitz Ross S, Nucci Marisa R, Crum Christopher P

Abstract excerpt

Human papillomavirus-negative keratinizing vulvar cancers typically harbor TP53 mutations as do their precursors, differentiated vulvar intraepithelial neoplasia. However, atypical verruciform proliferations are also associated with these malignancies and their pathogenesis is poorly understood. This study compared 11 atypical verruciform lesions, including atypical verruciform hyperplasia, vulvar acanthosis with...

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PMID: 27834349
DOI: 10.1038/modpathol.2016.187

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ARID2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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