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Article

Monocytes complexed to platelets differentiate into functionally deficient dendritic cells.

Journal of leukocyte biology - 1 Apr 2021

Singh Meera V, Suwunnakorn Sumanun, Simpson Sydney R, Weber Emily A, Singh Vir B, Kalinski Pawel, Maggirwar Sanjay B

Abstract excerpt

In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals and induce a proinflammatory monocyte phenotype. Because monocytes can act as precursors of dendritic cells...

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Identifiers

PMID: 32663904
DOI: 10.1002/JLB.3A0620-460RR
PMCID: PMC7854860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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