Article
Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, transendothelial migration, and cell surface phenotype.
The Journal of clinical investigation - 1 Apr 1995
Trial J, Birdsall H H, Hallum J A, Crane M L, Rodriguez-Barradas M C, de Jong A L, Krishnan B, Lacke C E, Figdor C G, Rossen R D
Abstract excerpt
We postulated that changes in the cell surface display of molecules that facilitate cell-cell and cell-matrix adhesions may reflect the changing immunosurveillance capacity of blood monocytes during progression of human immunodeficiency virus (HIV) infections. In Centers for Disease Control (CDC) stage A patients, whose monocytes' ability to phagocytose bacteria and generate reactive oxygen intermediates is often...
Topics
- Antigen-Antibody Complex
- Antigens, CD
- Apoptosis
- Cell Movement
- Complement System Proteins
- Cytokines
- HIV Infections
- HLA Antigens