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Article

Inhibition of AMPK activity in response to insulin in adipocytes: involvement of AMPK pS485, PDEs, and cellular energy levels.

American journal of physiology. Endocrinology and metabolism - 1 Sept 2020

Kopietz Franziska, Rupar Kaja, Berggreen Christine, Säll Johanna, Vertommen Didier, Degerman Eva, Rider Mark H, Göransson Olga

Abstract excerpt

Insulin resistance in obesity and type 2 diabetes has been shown to be associated with decreased de novo fatty acid (FA) synthesis in adipose tissue. It is known that insulin can acutely stimulate FA synthesis in adipocytes; however, the mechanisms underlying this effect are unclear. The rate-limiting step in FA synthesis is catalyzed by acetyl-CoA carboxylase (ACC), known to be regulated through inhibitory...

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Identifiers

PMID: 32663099
DOI: 10.1152/ajpendo.00065.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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