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Article

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Mankouri Jamel, Tedbury Philip R, Gretton Sarah, Hughes Mair E, Griffin Stephen D C, Dallas Mark L, Green Kevin A, Hardie D Grahame, Peers Chris, Harris Mark

Abstract excerpt

Hepatitis C virus (HCV) infection is associated with dysregulation of both lipid and glucose metabolism. As well as contributing to viral replication, these perturbations influence the pathogenesis associated with the virus, including steatosis, insulin resistance, and type 2 diabetes. AMP-activated protein kinase (AMPK) plays a key role in regulation of both lipid and glucose metabolism. We show here that, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20534540
DOI: 10.1073/pnas.0912426107
PMCID: PMC2895084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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