Article

Decomposition of transcriptional responses provides insights into differential antibiotic susceptibility

2020-05-04

Abstract excerpt

Responses of bacteria to antibiotic treatments depend on their environments. Differences between in vitro testing conditions and the physiological environments inside patients have resulted in poor antibiotic susceptibility predictions, contributing to treatment failures in the clinic. Here, we investigate how media composition affects antibiotic susceptibility in the laboratory strain E. coli K-12 MG1655, and c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbdca8a8-085b-5aec-9806-e3b18b810ab7
DOI: 10.1101/2020.05.04.077271

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decomposition of transcriptional responses provides insights into differential antibiotic susceptibilityDOI 10.1101/2020.05.04.077271Read

Machine Learning of Bacterial Transcriptomes Reveals Responses Underlying Differential Antibiotic SusceptibilitySemantic proximity Read

Revealing Transcriptomic Responses in <i>Escherichia coli</i> During Early Antibiotic ExposureSemantic proximity Read

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivitySemantic proximity Read

Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic ClassSemantic proximity Read

Diversity and evolution of the transcriptional regulatory networks of <i>Pseudomonas</i> strains revealed using machine learningSemantic proximity Read

Microbial forensics: predicting phenotypic characteristics and environmental conditions from large-scale gene expression profiles.Semantic proximity Read

Transcriptomic responses to antibiotic exposure in Mycobacterium tuberculosisSemantic proximity Read

An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli.Semantic proximity Read

Unraveling bacterial stress responses: implications for next-generation antimicrobial solutionsSemantic proximity Read

Clinical Pilot of Bacterial Transcriptional Profiling as a Combined Genotypic and Phenotypic Antimicrobial Susceptibility TestSemantic proximity Read

Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Semantic proximity Read

Advanced transcriptomic analysis reveals the role of efflux pumps and media composition in antibiotic responses of <i>Pseudomonas aeruginosa</i>Semantic proximity Read