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Article

OptDesign: Identifying Optimum Design Strategies in Strain Engineering for Biochemical Production.

ACS synthetic biology - 15 Apr 2022

Jiang Shouyong, Otero-Muras Irene, Banga Julio R, Wang Yong, Kaiser Marcus, Krasnogor Natalio

Abstract excerpt

Computational tools have been widely adopted for strain optimization in metabolic engineering, contributing to numerous success stories of producing industrially relevant biochemicals. However, most of these tools focus on single metabolic intervention strategies (either gene/reaction knockout or amplification alone) and rely on hypothetical optimality principles (e.g., maximization of growth) and precise gene...

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Identifiers

PMID: 35389631
DOI: 10.1021/acssynbio.1c00610
PMCID: PMC9016760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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