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Article

Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2020

Melnikov Sergey V, Stevens David L, Fu Xian, Kwok Hui Si, Zhang Jin-Tao, Shen Yue, Sabina Jeffery, Lee Kevin, Lee Harry, Söll Dieter

Abstract excerpt

Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through experimental evolution in a microfluidics-based turbidostat, we demonstrate that antibiotic-resistant cells can be efficiently inhibited by amplifying the fitness costs associated with drug-resistance evolution. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32661175
DOI: 10.1073/pnas.2003132117
PMCID: PMC7395499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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